William E Delaney Selected Research

Toll-Like Receptor 8

1/2021	Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
1/2020	Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.

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William E Delaney Research Topics

Disease

18	Infections 01/2023 - 08/2002
18	Chronic Hepatitis B 01/2023 - 08/2002
3	Hepatitis B 07/2013 - 12/2003
2	Viremia 03/2020 - 07/2005
2	Persistent Infection 02/2012 - 06/2004
1	Disease Progression 11/2022
1	Genetic Translocation (Chromosomal Translocation) 01/2021
1	Hepatitis C 12/2014
1	Coinfection 05/2007
1	HIV Infections (HIV Infection) 07/2005
1	Body Weight (Weight, Body) 07/2005

Drug/Important Bio-Agent (IBA)

9	Antiviral Agents (Antivirals)IBA 01/2022 - 06/2004
7	adefovir dipivoxil (Hepsera)FDA Link 05/2007 - 08/2002
5	NucleotidesIBA 05/2013 - 01/2005
5	NucleosidesIBA 05/2013 - 07/2003
4	Lamivudine (Epivir)FDA Link 05/2007 - 11/2003
3	Circular DNAIBA 01/2023 - 12/2003
3	GS-9256IBA 01/2017 - 02/2012
3	adefovirIBA 05/2007 - 07/2003
2	AntigensIBA 01/2023 - 07/2005
2	Toll-Like Receptor 8IBA 01/2021 - 01/2020
2	selgantolimodIBA 01/2021 - 01/2020
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 12/2003
2	vesatolimodIBA 01/2018 - 01/2018
2	Toll-Like Receptor 7IBA 01/2018 - 01/2018
2	InterferonsIBA 01/2017 - 05/2013
2	GS-9451IBA 12/2014 - 01/2014
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2014 - 07/2009
2	Hepatitis B e AntigensIBA 05/2007 - 01/2003
2	ProTidesIBA 05/2007 - 01/2007
2	Tenofovir (Viread)FDA Link 07/2006 - 07/2005
1	RNA (Ribonucleic Acid)IBA 01/2023
1	nasIBA 01/2023
1	Biomarkers (Surrogate Marker)IBA 11/2022
1	histone H3 trimethyl Lys4IBA 01/2022
1	Peptides (Polypeptides)IBA 03/2020
1	Taurocholic Acid (Sodium Taurocholate)IBA 03/2020
1	hepatitis B virus X proteinIBA 01/2017
1	CytokinesIBA 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 12/2014
1	phosphonic acidIBA 07/2009
1	Interferon-alpha (Interferon Alfa)IBA 05/2007
1	ProdrugsIBA 07/2006
1	Surface Antigens (Surface Antigen)IBA 07/2005
1	Codon (Codons)IBA 01/2003
1	Proteins (Proteins, Gene)FDA Link 01/2003

Therapy/Procedure

10	Therapeutics 03/2020 - 08/2002
1	Aftercare (After-Treatment) 05/2013
1	Liver Transplantation 05/2007
1	Oral Administration 07/2005